Tracking the relevant researches of CADD drug development against COVID-19


Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. [Uniprot]


Catalytic pocket

Receptor: 6W01

Pocket Residues:

Chain A: H235 I236 D240 H243 Q245 L246 G247 G248 H250 L251 F269 N278 F280 S289 K290 C291 V292 S294 I296 F303 V315 S316 F330 M331 W333 C334 K335 E340 T341 F342 Y343 P344 K345 L346