Tracking the relevant researches of CADD drug development against COVID-19
Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. Acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens. [Uniprot]
Chain A: T5 G6 L7 K9 S56 M57 M58 G59 F60 K61 D90 V91 E92 G93 C94 H95 V101 G102 T103 N104 L107 K139 P140 P141 P142 G143 D144 Q145 F146 K147 H148 L149 I150 P151 W159 W186 A187 H188 G189 F190 E191 Y197 D243 V244 Q245 Q246 F249 G251 N252 L253 Q254 S255 D258 N266 H268 A270 D273 T277
Chain A: I80 R81 C285 F286 V287 K288 R289 V290 D291 W292 T293 I294 E295 Y296 I298 E302 L303 I305 N306 A307 A308 C309 R310 K311 V312 Q313 H314 L329 D331 I332 G333 N334 P335 K336 A337 I338 K339 C340 P342 Q343 W348 F350 Y351 D352 A353 Q354 P355 C356 S357 D358 K359 A360 K362 E365 L366 F367 Y368 F377 W385 N386 C387 N388 V389 C399 F401 D402 L419 Y420 V421 N422 K423 H424 A425 F426 H427 T428 P429 M501 G505 F506 S507 L508