Tracking the relevant researches of CADD drug development against COVID-19
Cefpiramide is a third-generation cephalosporin antibiotic. [DrugBank]
Peptidoglycan synthase FtsI (Escherichia coli (strain K12)); Penicillin-binding protein 1B (Escherichia coli (strain K12)); Penicillin-binding protein 1A (Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)); Penicillin-binding protein 1B (Pseudomonas aeruginosa); D-alanyl-D-alanine carboxypeptidase DacC (Escherichia coli (strain K12)); Penicillin-binding protein 1A (Escherichia coli (strain K12)); Penicillin binding protein 2a (Staphylococcus aureus) [DrugBank]
Cefpiramide is a cephalosporin active against Pseudomonas aeruginosa. It has a broad spectrum of antibacterial activity. Cefpiramide works by inhibiting bacterial cell wall biosynthesis. The plasma half-lives of cefpiramide in rabbits, dogs, and rhesus monkeys were much longer than those of cefoperazone and cefazolin. [DrugBank]
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Cefpiramide (CPM) in the SMILES input box.
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Cefpiramide (CPM) to perform blind docking.