Tracking the relevant researches of CADD drug development against COVID-19
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin®. [DrugBank]
P2Y purinoceptor 2 (Humans); NAD-dependent protein deacylase sirtuin-5, mitochondrial (Humans); Follicle-stimulating hormone receptor (Humans); Ryanodine receptor 1 (Humans); Prothrombin (Humans); Phospholipase A2, membrane associated (Humans); Complement control protein C3 (VACV) [DrugBank]
Not Available [DrugBank]
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Suramin in the SMILES input box.
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Suramin to perform blind docking.