DrugBank ID:

DB00115

Description:

Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria, and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, methyl-, deoxyadenosyl- and hydroxy-cobalamin forms. Thecyanoform, is the most widely used form in supplements and prescription drugs. Several pharmaceutical forms of cyanocobalamin have been developed, including the tablet, injection, and nasal spray forms. This drug was initially approved by the FDA in 1942. [DrugBank]

Targets:

Methionine synthase (Humans); Methylmalonyl-CoA mutase, mitochondrial (Humans); Methionine synthase reductase (Humans); Methylmalonic aciduria type A protein, mitochondrial (Humans); Methylmalonic aciduria and homocystinuria type C protein (Humans); Methylenetetrahydrofolate reductase (Humans) [DrugBank]

Pharmacodynamics:

General effects [DrugBank]

SMILES:

C/C1=C2/N=C(/C=C3\N=C(/C(C)=C4\[N-][C@@](C)([C@@H]5N=C1[C@](C)(CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@@H]1[C@@H](CO)O[C@H](n6cnc7cc(C)c(C)cc76)[C@@H]1O)[C@H]5CC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]2CCC(N)=O.[C-]#N.[Co+3]

2D structures:  

3D structures: