Procainamide
Function
DrugBank ID:
Description:
A derivative of procaine with less CNS action. [DrugBank]
Targets:
Sodium channel protein type 5 subunit alpha (Humans); DNA (cytosine-5)-methyltransferase 1 (Humans); Potassium voltage-gated channel subfamily H member 2 (Humans) [DrugBank]
Pharmacodynamics:
Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Procainamide appears to be similar to that of procaine and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. [DrugBank]
Structures
Docking in target protein
Off-target analysis based on ligand similarity (Homo sapiens)
Step 1 - Target prediction for Procainamide: SwissTargetPrediction
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Procainamide in the SMILES input box.
Step 2 - Blind docking for Procainamide: CB-Dock
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Procainamide to perform blind docking.