DrugBank ID:

DB01016

Description:

Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II.It is typically given to patients who cannot be managed with the standard first line therapy,metformin.Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ion concentrations.Glyburide was granted FDA approval on 1 May 1984.A formulation with metformin was granted FDA approval on on 31 July 2000. [DrugBank]

Targets:

Sulfonylurea receptor 1, Kir6.2 (Humans); ATP-binding cassette sub-family C member 9 (Humans); Bile salt export pump (Humans); ATP-binding cassette sub-family A member 1 (Humans); Mitochondrial ATP-sensitive potassium channel (Humans); Carnitine O-palmitoyltransferase 1, liver isoform (Humans); Cystic fibrosis transmembrane conductance regulator (Humans); Transient receptor potential cation channel subfamily M member 4 (Humans) [DrugBank]

Pharmacodynamics:

Glyburide is a second generation sulfonylurea8 that stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ion concentrations.7 Glibenclamide has a long duration of action as it is given once daily, and a wide therapeutic index as patients are started at doses as low as 0.75mg but that can increase as high as 10mg or more.9,12 Patients taking glyburide should be cautioned regarding an increased risk of cardiovascular mortality as seen with tolbutamide, another sulfonylurea.12 [DrugBank]

SMILES:

COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1

2D structures:  

3D structures: