Alprazolam
Function
DrugBank ID:
Description:
Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.Alprazolam's adverse effects are generally related to the sedation it can cause.Alprazolam has been mixed with alcohol as a drug of abuse to potentiate the sedative effects of the drug which may lead to coma and death.Alprazolam was given FDA approval on October 16, 1981. [DrugBank]
Targets:
GABA(A) Receptor (Humans); GABA(A) Receptor Benzodiazepine Binding Site (Humans) [DrugBank]
Pharmacodynamics:
Alprazolam is indicated to treat anxiety and panic disorders.Label The mechanism by which its cell receptor interactions translate to a clinical effect is not known.Label,3,4 [DrugBank]
Structures
Docking in target protein
Off-target analysis based on ligand similarity (Homo sapiens)
Step 1 - Target prediction for Alprazolam: SwissTargetPrediction
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Alprazolam in the SMILES input box.
Step 2 - Blind docking for Alprazolam: CB-Dock
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Alprazolam to perform blind docking.